A native of Houston, Luckett grew up singing in the children's choir of her local church and performing in plays at her elementary school, where she met Beyoncé Knowles. In 1993, Luckett joined the group Destiny’s Child alongside Knowles, Kelly Rowland and LaTavia Roberson. Graduating from the Houston club scene, the group began opening for such acts as Dru Hill, S.W.V., and Immature. Columbia Records signed Destiny’s Child in 1997 and in 1998, they released their self-titled debut album, Destiny's Child, which included the singles "No, No, No" featuring Wyclef Jean and "With Me." They were also featured on the "Why Do Fools Fall in Love" soundtrack with the song "Get on the Bus" featuring Tim Mosley (aka Timbaland).

After touring as an opening act on TLC’s "Fanmail Tour" and Christina Aguilera’s debut tour, in 1999, the group released their sophomore album, The Writing's on the Wall. It became one of the biggest selling albums released by a female group and was certified platinum eight times in the U.S. After a break with the group, in 2003, Luckett decided to pursue a solo career and signed with Capitol Records. She immediately began working on her debut solo album and, in 2004, she released her first track, "You Got What I Need." Her self-titled debut album, LeToya, was released on July 25, 2006 debuting at number one on the U.S. Billboard 200 and has been certified platinum. LeToya began to pursue a career in acting in 1999 and has since appeared in numerous television and film roles including the critically acclaimed and award-winning HBO series “Treme," and feature films "Killers," "The Preacher’s Kid" and "From the Rough." She is currently filming the indie film "Note to Self."